Resistance management for sustainable agriculture and improved public health

Red flour beetle

Tribolium castaneum

The red flour beetle (Tribolium castaneum) is an important pest of stored grains and agricultural produce world wide. Originating in the Asia-Pacific region, global food transportation has held re-distribute this pest globally, ensuring its place as one of the most important pest species of stored produce. Both the adult beetle and its larvae feed on stored legumes, nuts, cereals and other grains. Female beetles can lay up t0 400 eggs and live for approximately 6 to 8 months.

The red flour beetle has developed resistance to many of the control methods that have been used for its control and as a result of the global transport of stored produce, resistant populations have been able to establish in almost all parts of the globe. Resistance to organophosphates, carbamates, cyclodienes, pyrethroids, DDT and fumigants have been recorded in North and South America, Europe, Africa and the Asia-Pacific region, making control of this pest difficult

Red flour beetle resistance profile

Resistance to organophosphate insecticides has been reported in most of the regions of the world. Resistance is based on enhanced metabolism by carboxylesterase enzymes. The differences in carboxylesterases specificity means that cross resistance amongst the acetylcholinesterase inhibitors (organophosphates and carbamates) is variable depending on the up regulated enzyme. Resistance to cyclodiene insecticides has also been well documented globally. Here resistance is associated with a target site mutation in the GABA-gated chloride channel. This A302S mutation is often called RdL resistance. Resistance to pyrethroid insecticides, DDT and phosphine fumigants have all been recorded in various populations of the red flour beetle, reducing the number of effective control solutions available to grain store managers. Although resistance to insecticides has been reported extensively in many locations around the world, not all populations of beetles are resistant and it is recommended to consult with local experts to determine the best control solution for these pests.

Species Distribution Chemical class Mechanisms
Tribolium castaneum Global Carbamates (1A) Malathion Carboxylestearse Non-specific esterases Glutathione s-transferase
Tribolium castaneum Global Organophosphates (1B) Non-specific esterases Glutathione s-transferase
Tribolium castaneum Global Cyclodiene organochlorines (2A) RdL (A302S) target site mutation
Tribolium castaneum Global Pyrethroids-Pyrethrins (3A) P450 Monoxygenase (CYP6BQ9) Glutathione s-transferase
Tribolium castaneum Global DDT (3B) Unkown
Tribolium castaneum Global Phosphides (24A) Reduced uptake and enhanced metabolism

References

Title Year Author(s) Publisher
Insecticide Resistance and Management Strategies in Urban Ecosystems Vol. 7(1):2. DOI:10.3390/insects7010002. 2016 Zhu F, Lavine L, O’Neal S, Lavine M, Foss C, Walsh D Insects
Insecticide resistance in stored-product insects with special reference to Tribolium castaneum Tropical Stored Products Information, No.20 pp.13-18 pp. ref.16 1970 Dyte CE Tropical Stored Products Centre

The information provided is based on literature reviews and as such IRAC cannot guarantee or be held accountable for the accuracy of the reports.

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