The IRAC Mode of Action Working Group have developed a set of 74 slides as a MoA tutorial outlining the major mechanisms of insecticide resistance and, explaining with graphics, MoA by the targeted physiology affected using the broad categories of: Nerve and Muscle, Growth and Development, Respiration, Midgut and Unknown or Non-specific target sites or functions.
In a situation in which running real-world experiments is impractical (or even impossible), computer simulations offer a powerful solution to understand complex problems. This is exactly the case of resistance-evolution prediction: Although fast from an evolutionary perspective, the time and spatial scales involved in this process are simply too large to be dealt with experimentally. The underlying evolutionary processes of resistance development are relatively well known, however. With this knowledge, researchers can build mathematical models to describe and mimic the actual systems. These models can also be calibrated based on real-world cases that have already occurred, improving their precision and accuracy. Read the full paper
A video from CropLife International and the Insecticide Resistance Action Committee (IRAC) that explains the importance of mode of action as the basis for effective and sustainable resistance management to preserve the utility and diversity of available insecticides and acaricides. The video can be viewed in English or watch it in Spanish, Mandarin or Portuguese.
The application of an insecticide to the soil, either as a seed treatment or as a direct application, is designed to either control soil borne insect pests or provide systemic control of pests above the ground. The general principles of resistance management apply to seed and soil treatments, as with foliar applied insecticides, however there are some additional factors that should be considered as outlined the the latest statement from IRAC titled: IRAC International statement on the resistance management considerations of utilizing soil & seed applied insecticides
The new IRAC leaflet has been designed in conjunction with CropLife International providing growers with essential information on insect resistance management and the significant benefits for growers. The leaflet is in English at the moment but an editable version will be available shortly so that it can be translated into the local languages and targeted for specific countries and sectors.
The MoA Classification has been updated by the IRAC MoA Team and the updates approved by the IRAC Executive. The latest version of the Classification Scheme can be downloaded from the IRAC website. The English version of the IRAC Chemical Structures Poster and the small IRAC MoA Booklet have also been update and can be downloaded from the website.
In this issue we focus on mode of action (MoA) and its importance in insecticide resistance management (IRM). We present a review paper on IRM and the IRAC MoA Classification and summarize the changes that have been made to the latest version of the classification scheme.
Download a copy of the newsletter for full details of these articles and find out more about MoA using the links below.